rna, small interfering

Preferred Label : rna, small interfering;

MeSH definition : Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.;

MeSH synonym : small interfering rna; interfering rna, small; sirna; short interfering RNA; interfering RNA, short; RNA, short interfering;

MeSH hyponym : Piwi-Interacting RNA; scan RNA; short hairpin RNA; Trans-Acting siRNA; Piwi Interacting RNA; RNA, Piwi-Interacting; RNA, Piwi Interacting; piRNA; Hairpin RNA, Short; RNA, Short Hairpin; Small Hairpin RNA; Hairpin RNA, Small; RNA, Small Hairpin; shRNA; scnRNA; Small Scan RNA; RNA, Small Scan; Scan RNA, Small; RNA, Scan; Trans Acting siRNA; tasiRNA; siRNA, Trans-Acting; siRNA, Trans Acting;

Related MeSH term : Repeat-Associated siRNA; Repeat Associated siRNA; siRNA, Repeat-Associated; siRNA, Repeat Associated;

MeSH annotation : Do not confuse with defective interfering RNA (diRNA), a viral RNA of DEFECTIVE VIRUSES.;

Wikipedia link : https://en.wikipedia.org/wiki/Sirna;

Is substance : O;

Details

Origin ID

D034741;

UMLS CUI

C1099354;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Piwi-Interacting RNA [NCIt concept]
- Short Hairpin RNA [NCIt concept]
Currated CISMeF NLP mapping
- Small Interfering RNA [NCIt concept]
Indexing information
- MPG-8 peptide [MeSH Supplementary Concept]
Manual BTNT mappings - CISMeF
- PIWI-interacting ribonucleic acid [OMIConto structure]
Record concept(s)
- RNA, small interfering [MeSH concept]
- Repeat-Associated siRNA [MeSH concept]
- Trans-Acting siRNA [MeSH concept]
- scan RNA [MeSH concept]
- short hairpin RNA [MeSH concept]
Related MeSH Supplementary Concept(s)
- ALN-PCS [MeSH Supplementary Concept]
- ARC-520 [MeSH Supplementary Concept]
- Atu027 [MeSH Supplementary Concept]
- CALAA-01 [MeSH Supplementary Concept]
- DFP-10825 [MeSH Supplementary Concept]
- ISIS 121736 [MeSH Supplementary Concept]
- PF-04523655 [MeSH Supplementary Concept]
- SG220 compound [MeSH Supplementary Concept]
- SG273 compound [MeSH Supplementary Concept]
- TKM-080301 [MeSH Supplementary Concept]
- TKM-130803 [MeSH Supplementary Concept]
- bevasiranib [MeSH Supplementary Concept]
- fitusiran [MeSH Supplementary Concept]
- lumasiran [MeSH Supplementary Concept]
- olpasiran [MeSH Supplementary Concept]
- patisiran [MeSH Supplementary Concept]
- revusiran [MeSH Supplementary Concept]
See also
- MicroRNAs [MeSH Descriptor]
- rna interference [MeSH Descriptor]
- rna-induced silencing complex [MeSH Descriptor]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
UMLS correspondences (same concept)
- Small Interfering RNA [NCIt concept]
- Small interfering ribonucleic acid (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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