Preferred Label : rna-induced silencing complex;
MeSH definition : A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE
PROTEINS and the guide strand of the one of the 20- to 30-nucleotide small RNAs. RISC
cleaves specific RNAs, which are targeted for degradation by homology to these small
RNAs. Functions in regulating gene expression are determined by the specific argonaute
protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA),
or piRNA (PIWI-INTERACTING RNA).;
MeSH synonym : complex, rna-induced silencing; multicomponent nuclease, risc; nuclease, risc multicomponent; risc multicomponent nuclease; silencing complex, rna-induced; RNA induced silencing complex;
Is substance : O;
Origin ID : D034743;
UMLS CUI : C1099355;
Allowable qualifiers
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
Record concept(s)
See also
Semantic type(s)
UMLS correspondences (same concept)
A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE
PROTEINS and the guide strand of the one of the 20- to 30-nucleotide small RNAs. RISC
cleaves specific RNAs, which are targeted for degradation by homology to these small
RNAs. Functions in regulating gene expression are determined by the specific argonaute
protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA),
or piRNA (PIWI-INTERACTING RNA).