RNA-Induced Silencing Complex

Preferred Label : RNA-Induced Silencing Complex;

NCIt synonyms : RISC;

NCIt definition : A RNA-protein complex that catalyzes facilitates the association of either a microRNA or a small interfering RNA with its complementary coding RNA and then degrades the targeted coding RNA molecule.;

NCIt note : This complex is active in both miRNA-dependent gene regulation, and the response to viral infection.;

Details

Origin ID

C84404;

UMLS CUI

C1099355;

Currated CISMeF NLP mapping
- RNA-Induced silencing complex [MeSH concept]
- rna-induced silencing complex [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
UMLS correspondences (same concept)
- RNA-Induced silencing complex [MeSH concept]
- rna-induced silencing complex [MeSH Descriptor]
gene_product_is_element_in_pathway
- Double Stranded RNA Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- RNA Degradation [NCIt concept]
- RNA Interference [NCIt concept]
- Translational Regulation [NCIt concept]
has_gene_product_element
- Helicase MOV-10 [NCIt concept]
- Protein Argonaute-1 [NCIt concept]
- Protein Argonaute-2 [NCIt concept]
- Protein Argonaute-3 [NCIt concept]
- Protein Argonaute-4 [NCIt concept]
- RISC-Loading Complex Subunit TARBP2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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