Preferred Label : Double Stranded RNA Biosynthesis Pathway;
NCIt synonyms : dsRNA Biosynthesis Pathway; RNA Interference Pathway;
NCIt related terms : Antisense Pathway;
Alternative definition : BIOCARTA: About 8% of human genes have been estimated to carry out transcription from
both DNA strands, resulting in significant level of endogenous antisense RNA. In the
cytoplasm the antisense RNA leads to formation of long dsRNA, which activates the
interferon and RNA-dependent protein kinase antiviral pathway. Most endogenous antisense
RNA is made in the nucleus and two responses have been suggested for the nuclear dsRNA.
First, the dsRNA may be processed by enzymes of the family of adenosine deaminases
that act on RNA (ADAR). The deaminated dsRNAs contain various levels of inosines.
dsRNA containing high level of inosines are tightly bound by a protein complex that
results in their nuclear retention. dsRNA containing low level of inosines may be
able to exit the nucleus. Second, the nuclear dsRNA can lead to gene silencing and
heterochromatin formation. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_antisensePathway;
Origin ID : C38987;
UMLS CUI : C1514665;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
