NCIt definition : Human NONO wild-type allele is located in the vicinity of Xq13.1 and is approximately
18 kb in length. This allele, which encodes non-POU domain containing, octamer-binding
protein, may play a role in the mediation of transcription, RNA splicing and DNA secondary
structure. The gene can be involved in an inversion inv(X)(p11.2;q12) with the TFE3
gene in some papillary renal cell carcinomas.;
NCIt note : A complex of the NONO gene product and the SFPQ gene product may play a role in both
RNA splicing and the nuclear retention of defective RNAs. (FEBS Lett. 2002; 531:109-14.);