Proprotein Convertase 9

Preferred Label : Proprotein Convertase 9;

MeSH definition : A proprotein convertase that is essential for CHOLESTEROL homeostasis. It binds to and is required for the lysosomal degradation of the LDL RECEPTOR (LDLR); the VLDL receptor, and the APOLIPOPROTEIN E RECEPTOR. It also regulates neuronal APOPTOSIS.;

MeSH synonym : Convertase 9, Proprotein; Neural Apoptosis-Regulated Convertase 1; Neural Apoptosis Regulated Convertase 1; NARC-1 Protein; NARC 1 Protein; Proprotein Convertase, Subtilisin-Kexin Type 9; Proprotein Convertase, Subtilisin Kexin Type 9;

Registry Number MeSH : EC 3.4.21.-;

Details

Origin ID

D000071449;

UMLS CUI

C4255394;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- PCSK9 Gene [NCIt concept]
- Proprotein Convertase Subtilisin/Kexin Type 9 [NCIt concept]
- Proprotein convertase subtilisin/kexin type 9 inhibitor (disposition) [SNOMED CT concept]
- Proprotein convertase, subtilisin/kexin-type, 9 [OMIM gene]
- proprotein convertase subtilisin/kexin type 9 [ORDO Gene]
- proprotein convertase subtilisin/kexin type 9 [HGNC gene]
CISMeF manual mappings
- Substance with proprotein convertase subtilisin/kexin type 9 inhibitor mechanism of action (substance) [SNOMED CT concept]
Record concept(s)
- Proprotein Convertase 9 [MeSH concept]
Related MeSH Supplementary Concept(s)
- PCSK9 protein, human [MeSH Supplementary Concept]
- PCSK9 protein, rat [MeSH Supplementary Concept]
- Pcsk9 protein, mouse [MeSH Supplementary Concept]
Related MeSH term(s)
- PCSK9 Inhibitors [MeSH Descriptor]
See also (suggested by CISMeF)
- alirocumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

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