zidovudine - CISMeF

Preferred Label : zidovudine;

MeSH definition : A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.;

MeSH synonym : 3'-azido-3'-deoxythymidine; 3' azido 3' deoxythymidine; azt, antiviral; antiviral azt; azt (antiviral); azt antiviral; 3'-azido-2',3'-dideoxythymidine; 3' azido 2',3' dideoxythymidine; azidothymidine;

MeSH hyponym : BW A509U; BWA-509U; BWA 509U; BWA509U;

Related MeSH term : retrovir;

MeSH CAS label : thymidine, 3'-azido-3'-deoxy-;

MeSH Related Number : 30516-87-1 (Zidovudine);

Registry Number MeSH : 30516-87-1;

Wikipedia link : https://en.wikipedia.org/wiki/Zidovudine;

Is substance : O;

UNII : 4B9XT59T7S;

InChIKey : HBOMLICNUCNMMY-XLPZGREQSA-N;

Details

Origin ID

D015215;

UMLS CUI

C0043474;

ATC code(s)
- zidovudine [ATC Code]
- zidovudine, lamivudine and abacavir [ATC Code]
- zidovudine, lamivudine and nevirapine [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- Zidovudine adverse reaction (disorder) [SNOMED CT concept]
- zidovudine [Substance BNPC]
Currated CISMeF NLP mapping
- Product containing zidovudine (medicinal product) [SNOMED CT concept]
- Zidovudine [ICD-11 Extension code]
- Zidovudine [ICHI extension code]
- Zidovudine [SMS substance]
- Zidovudine [NCIt concept]
- Zidovudine [LOINC component]
- Zidovudine (substance) [SNOMED CT concept]
- zidovudine [SNOMED Notion]
Pharmacological action(s)
- anti-hiv agents [MeSH Descriptor]
- antimetabolites [MeSH Descriptor]
- reverse transcriptase inhibitors [MeSH Descriptor]
Record concept(s)
- BW A509U [MeSH concept]
- retrovir [MeSH concept]
- zidovudine [MeSH concept]
Related MeSH Supplementary Concept(s)
- (P(1)-thymidine-3'-azido-2',3'-dideoxyriboside-5')-P(2)-(9-2-(phosphonomethoxypropyl)adenine) [MeSH Supplementary Concept]
- 1,2-dimyristoylphosphatidylazidothymidine [MeSH Supplementary Concept]
- 1-((2-azido-1-(hydroxymethyl)ethoxy)methyl)thymine [MeSH Supplementary Concept]
- 1-(1-(2-hydroxyethoxy)-3-azidopropyl)thymine [MeSH Supplementary Concept]
- 1-(2-azido-2-deoxyarabinofuranosyl)thymine [MeSH Supplementary Concept]
- 1-(3-azido-2,3-dideoxy-2-fluoroarabinofuranosyl)thymine [MeSH Supplementary Concept]
- 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-beta-arabinofuranosyl)uracil [MeSH Supplementary Concept]
- 1-methyl-5-(3-azido-2,3-dideoxy-beta-pentofuranosyl)uracil [MeSH Supplementary Concept]
- 2'-azido-2',3'-dideoxythymidine [MeSH Supplementary Concept]
- 2-(mannopyranosidyl)ethyl 3'-azido-3'-deoxy-5'-thymidinyl phosphate [MeSH Supplementary Concept]
- 2-amino-9-(3-azido-2,3-dideoxy-erythro-pentofuranosyl)-6-(1-pyrrolidinyl)-9H-purine [MeSH Supplementary Concept]
- 3',5-diazido-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxy-5'-O-((1,4-dihydro-1-methyl-3-pyridyl)carbonyl)uridine [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxy-5-(N-15-(6-(3,5-dimethylphenylthio)-5-ethyl-1-(5-oxopentyl)uracil)-4,15-diaza-3-oxopentadecanyl)uridine [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxy-5-(N-9-(6-(3,5-dimethylphenylthio)-5-ethyl-1-(5-oxopentyl)uracil)-4,9-diaza-3-oxononanyl)uridine [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxy-N-(1-methoxycarbonyl-2-(3-indolyl)eth-1-yl)thymidine 5'-phosphoramidate [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxy-N-(1-methylaminocarbonyl-2-(3-indolyl)eth-1-yl)thymidine 5'-phosphoramidate [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxythymidine 5'-H-phoshonate [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxyuridine 5'-monophosphate [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxyuridine-5'-O-valinate [MeSH Supplementary Concept]
- 3'-azido-2'-deoxythymidine-5'-methylamino-L-tryptophanylphosphoramidate [MeSH Supplementary Concept]
- 3'-azido-3',5'-dideoxythymidine-5'-methylphosphonic acid diphosphate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxy-4-thiothymidine [MeSH Supplementary Concept]
- 3'-azido-3'-deoxy-5'-(1-hexadecylthio-2-methoxypropyl)phosphothymidine [MeSH Supplementary Concept]
- 3'-azido-3'-deoxy-5'-O-((11-hydroxy-3-oxo-17-androst-4-enyl)carbonyl)thymidine [MeSH Supplementary Concept]
- 3'-azido-3'-deoxy-5'-O-((16-cyano-11-hydroxy-3-oxo-17-androsta-1,4-dienyl)carbonyl)thymidine [MeSH Supplementary Concept]
- 3'-azido-3'-deoxy-5'-O-beta-glucopyranuronosylthymidine [MeSH Supplementary Concept]
- 3'-azido-3'-deoxy-5'-O-isonicotinoylthymidine [MeSH Supplementary Concept]
- 3'-azido-3'-deoxyarabinothymidine [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidin-5'-yl O-(4-hydroxybutyl)carbonate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine 5'-(3-(1-O-hexadecyl-2-O-methylglycerol)phosphate) [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine 5'-(O-hexadecyl)phosphate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine 5'-(beta,gamma-imido)triphosphate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine 5'-choline phosphate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine 5'-diphosphate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine 5'phosphate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine monophosphate diglyceride [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine triphosphate distearoylglycerol [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine-5'-((2-cyanoethyl)(24-ethylcholesta-5,22-dien-3-yl))phosphate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine-5'-((cholest-5-en-3-yl)(2-cyanoethyl))phosphate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine-5'-(4-bromophenyl methoxyalaninyl phosphate) [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine-5'-bis(3,3-diacetoxy-propyl)phosphate [MeSH Supplementary Concept]
- 3'-azido-3'-deoxythymidine-5'-methoxyalaninyl phosphate [MeSH Supplementary Concept]
- 3'-azido-5'-isocyano-3',5'-dideoxythymidine [MeSH Supplementary Concept]
- 3'-azidothymidine 5'-(p-methoxyphenyl methoxyalaninyl phosphate) [MeSH Supplementary Concept]
- 3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate [MeSH Supplementary Concept]
- 3'-azidothymidine-5'-bis(4-nitrophenyl)phosphate [MeSH Supplementary Concept]
- 4'-azidothymidine [MeSH Supplementary Concept]
- 4'-azidothymidine 5'-triphosphate [MeSH Supplementary Concept]
- 4'-seleno-AZT [MeSH Supplementary Concept]
- 5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine [MeSH Supplementary Concept]
- 5'-O-(1-adamantyl)-3'-azido-3'-deoxythymidine [MeSH Supplementary Concept]
- 5'-O-succinylzidovudine [MeSH Supplementary Concept]
- 5'-cholesteryl-ethyl-phosphoryl zidovudine [MeSH Supplementary Concept]
- 5'-isoleucyl 3'-azido-3'-deoxythymidine [MeSH Supplementary Concept]
- 5-Bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-methoxyphenyl)methoxyalaninyl phosphate [MeSH Supplementary Concept]
- 5-azidomethyl-2'-deoxyuridine [MeSH Supplementary Concept]
- 5-bromo-6,5'-epoxy-5,6-dihydro-3'-azido-3'-deoxythymidine [MeSH Supplementary Concept]
- 5-bromo-6-methoxy-5, 6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate [MeSH Supplementary Concept]
- 5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(4-bromophenyl methoxyalaninyl phosphate) [MeSH Supplementary Concept]
- 5-carboxyethyl-3'-azido-3'-deoxythymidine [MeSH Supplementary Concept]
- 6-glucopyranosyl 3'-azido-3'-deoxy-5'-thymidinyl phosphate [MeSH Supplementary Concept]
- 6-mannopyranosyl 3'-azido-3'-deoxy-5'-thymidinyl phosphate [MeSH Supplementary Concept]
- AZTp4A [MeSH Supplementary Concept]
- CP 92 [MeSH Supplementary Concept]
- KNI 1039 [MeSH Supplementary Concept]
- N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate [MeSH Supplementary Concept]
- N(4)-hexadecyl-2'-deoxyribocytidylyl-(3',5')-3'-azido-2',3'-deoxythymidine [MeSH Supplementary Concept]
- N(4)-palmitoyl-2'-deoxyribocytidylyl-(3',5')-3'-azido-2',3'-deoxythymidine [MeSH Supplementary Concept]
- O,O'-bis(3'-azido-3'-deoxythymidin-5'-yl)-O''-(2-((phenyloxy)carbonyl)phenyl)phosphate [MeSH Supplementary Concept]
- abacavir, lamivudine, and zidovudine drug combination [MeSH Supplementary Concept]
- azidothymidine homodinucleotide [MeSH Supplementary Concept]
- bis(4-acetoxybenzyl)zidovudine diphosphate [MeSH Supplementary Concept]
- bispivaloylthioethyl zidovudine monophosphate [MeSH Supplementary Concept]
- cholesteryl-phosphonyl zidovudine [MeSH Supplementary Concept]
- cyclosaligenyl 3'-azido-2',3'-dideoxythymidine monophosphate [MeSH Supplementary Concept]
- fozivudine tidoxil [MeSH Supplementary Concept]
- hydroxy tBuSATE phenylphosphotriester AZT derivative [MeSH Supplementary Concept]
- lamivudine, zidovudine drug combination [MeSH Supplementary Concept]
- phosphoceramide azidothymidine [MeSH Supplementary Concept]
- scriptene [MeSH Supplementary Concept]
- trans-(5S,6S)-5-bromo-6, 5'-epoxy-5,6-dihydro-3'-azido-3'-deoxythymidine [MeSH Supplementary Concept]
- tuftsin-AZT conjugate [MeSH Supplementary Concept]
- zidovudine 5'-monophosphate-mannose-albumin conjugate [MeSH Supplementary Concept]
- zidovudine triphosphate [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing zidovudine (medicinal product) [SNOMED CT concept]
- Zidovudine [ICD-11 Extension code]
- Zidovudine [NCIt concept]
- Zidovudine [LOINC component]
- Zidovudine (substance) [SNOMED CT concept]
- zidovudine [ATC Code]
- zidovudine [Substance BNPC]
- zidovudine [SNOMED Notion]
Validated automatic mappings to BTNT
- zidovudine [ATC Code]

Keyword's position in hierarchy(ies) :

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