dideoxynucleosides

Preferred Label : dideoxynucleosides;

MeSH definition : Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.;

MeSH synonym : ddnus;

MeSH hyponym : 2',3'-Dideoxynucleosides; dideoxyribonucleosides; 2',3' Dideoxynucleosides;

MeSH annotation : antivirals & antimetabolites;

Is substance : O;

Details

Origin ID

D015224;

UMLS CUI

C0012136;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Pharmacological action(s)
- antimetabolites [MeSH Descriptor]
- reverse transcriptase inhibitors [MeSH Descriptor]
Record concept(s)
- 2',3'-Dideoxynucleosides [MeSH concept]
- dideoxynucleosides [MeSH concept]
- dideoxyribonucleosides [MeSH concept]
Related MeSH Supplementary Concept(s)
- 1,2-dipalmitoylphosphatidyldideoxyguanosine [MeSH Supplementary Concept]
- 1-(2',3'-dideoxy-3'(hydroxymethyl)erythropentofuranosyl)cytosine [MeSH Supplementary Concept]
- 1-(2-fluoro-4-iodo-2,4-dideoxyxylopyranosyl)-2-nitroimidazole [MeSH Supplementary Concept]
- 2',3'-deoxy-D-apio-D-furanoadenosine [MeSH Supplementary Concept]
- 2',3'-didehydro-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 2',3'-dideoxy-2',3'-didehydroguanine nucleoside [MeSH Supplementary Concept]
- 2',3'-dideoxy-3'-O-methylthymidine [MeSH Supplementary Concept]
- 2',3'-dideoxy-3'-aminoadenosine [MeSH Supplementary Concept]
- 2',3'-dideoxy-3'-fluoro-2-thiothymidine [MeSH Supplementary Concept]
- 2',3'-dideoxy-6-iodoguanosine [MeSH Supplementary Concept]
- 2',3'-dideoxy-N(6)-cyclohexyladenosine [MeSH Supplementary Concept]
- 2',3'-dideoxycarbocyclic thymidine [MeSH Supplementary Concept]
- 2',3'-dideoxyformycin A [MeSH Supplementary Concept]
- 2',3'-dideoxyguanosine [MeSH Supplementary Concept]
- 2',3'-dideoxythymidine [MeSH Supplementary Concept]
- 2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 2',5'-dichloro-2',5'-dideoxyuridine [MeSH Supplementary Concept]
- 2'-chloro-2',3'-dideoxyuridinene [MeSH Supplementary Concept]
- 2'-fluoro-2',3'-dideoxyguanosine [MeSH Supplementary Concept]
- 2'-methylcarbovir [MeSH Supplementary Concept]
- 2,6-diaminopurine 2',3'-didehydro-2',3'-dideoxyriboside [MeSH Supplementary Concept]
- 3' (3-(2-chloroethyl)-3-nitrosoureido)-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 3',3'-difluoro-3'-deoxythymidine [MeSH Supplementary Concept]
- 3',5'-dideoxythymidine [MeSH Supplementary Concept]
- 3'-(3-(2-chloroethyl)-3-nitrosourea)-3'-deoxythymidine [MeSH Supplementary Concept]
- 3'-(3-(2-chloroethyl)-3-nitrosoureido)-2',3'-dideoxy-5-fluorouridine [MeSH Supplementary Concept]
- 3'-C-methylidene-2',3'-dideoxy-5-methyluridine [MeSH Supplementary Concept]
- 3'-acetamido-2',3'-dideoxythymidine [MeSH Supplementary Concept]
- 3'-amino-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 3'-aminothymidine [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxyguanosine [MeSH Supplementary Concept]
- 3'-deoxy-2',3'-didehydro-2'fluorothymidine [MeSH Supplementary Concept]
- 3'-deoxy-3'-iodothymidine [MeSH Supplementary Concept]
- 3'-fluoro-2',3'-dideoxy-5-bromouridine [MeSH Supplementary Concept]
- 3'-fluoro-2',3'-dideoxy-5-iodouridine [MeSH Supplementary Concept]
- 3'-fluoro-2',3'-dideoxyguanosine [MeSH Supplementary Concept]
- 3'-fluoro-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 3'-isocyano-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 3'-methylamino-2',3'-dideoxyribosylthymine [MeSH Supplementary Concept]
- 3'-thio-3'-deoxythymidine [MeSH Supplementary Concept]
- 3'amino-3'-deoxy-5'-glucopyranuronosylthymidine [MeSH Supplementary Concept]
- 5'-amino-2',5'-dideoxyguanosine [MeSH Supplementary Concept]
- 5'-amino-5'-deoxythymidine [MeSH Supplementary Concept]
- 5'-deoxy-5'fluorothymidine [MeSH Supplementary Concept]
- 5'-isocyano-2',5'-dideoxyuridine [MeSH Supplementary Concept]
- 5'-isocyano-5'-deoxythymidine [MeSH Supplementary Concept]
- 5-bromo-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 5-bromo-6-methoxy-5,6-dihydro-3'-fluoro-3'-deoxythymidine [MeSH Supplementary Concept]
- 5-fluoro-2',3'-dideoxy-3'-fluorouridine [MeSH Supplementary Concept]
- 5-iodo-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 5-iodo-6-methoxy-5,6-dihydro-3'-fluoro-3'-deoxythymidine [MeSH Supplementary Concept]
- 5-o-carboranyl-2',3'-didehydro-2',3'-dideoxyuridine [MeSH Supplementary Concept]
- 6-aminocarbovir [MeSH Supplementary Concept]
- 6-chloro-2',3'-dideoxyguanosine [MeSH Supplementary Concept]
- 6-chloro-2',3'-dideoxyinosine [MeSH Supplementary Concept]
- 6-thioguanine-alpha-2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentafuranose [MeSH Supplementary Concept]
- 9-(c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl)-9H-adenine [MeSH Supplementary Concept]
- N,N'-dideoxythymidine-3,4,9,10-perylene-tetracarboxylic acid diimide [MeSH Supplementary Concept]
- N-(5'-adenosyl)-N'-(5'-thymidyl)azelaamide [MeSH Supplementary Concept]
- abacavir [MeSH Supplementary Concept]
- abacavir, dolutegravir, and lamivudine drug combination [MeSH Supplementary Concept]
- abacavir, lamivudine drug combination [MeSH Supplementary Concept]
- alovudine [MeSH Supplementary Concept]
- carbocyclic 3'-oxa-2',3'-dideoxy-7-deazaguanosine [MeSH Supplementary Concept]
- carbocyclic 3'-oxa-2',3'-dideoxyguanosine [MeSH Supplementary Concept]
- carbovir [MeSH Supplementary Concept]
- carbovir-5'-O-glucuronide [MeSH Supplementary Concept]
- norabacavir [MeSH Supplementary Concept]
- norcarbovir [MeSH Supplementary Concept]
- raluridine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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