zalcitabine - CISMeF

Preferred Label : zalcitabine;

MeSH definition : A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.;

MeSH synonym : 2',3' dideoxycytidine; ddc (antiviral); dideoxycytidine; 2',3'-dideoxycytidine;

CISMeF synonym : roche brand of zalcitabine; Hoffman-La roche brand of zalcitabine;

MeSH hyponym : NSC-606170; hivid; NSC 606170; NSC606170; HIVID Roche;

MeSH CAS label : cytidine, 2',3'-dideoxy-;

MeSH Related Number : 7481-89-2 (Zalcitabine);

Registry Number MeSH : 7481-89-2;

Wikipedia link : https://en.wikipedia.org/wiki/Zalcitabine;

Is substance : O;

UNII : 6L3XT8CB3I;

InChIKey : WREGKURFCTUGRC-POYBYMJQSA-N;

Details

Origin ID

D016047;

UMLS CUI

C0012132;

ATC code(s)
- zalcitabine [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Product containing zalcitabine (medicinal product) [SNOMED CT concept]
- Zalcitabine [ICD-11 Extension code]
- Zalcitabine [LOINC component]
- Zalcitabine [NCIt concept]
- Zalcitabine (substance) [SNOMED CT concept]
- zalcitabine [SNOMED Notion]
Pharmacological action(s)
- anti-hiv agents [MeSH Descriptor]
- antimetabolites [MeSH Descriptor]
- reverse transcriptase inhibitors [MeSH Descriptor]
Record concept(s)
- NSC-606170 [MeSH concept]
- hivid [MeSH concept]
- zalcitabine [MeSH concept]
Related MeSH Supplementary Concept(s)
- 1,2-dioleoyl-glycero-3-phospho-5'-(2',3')-dideoxycytidine [MeSH Supplementary Concept]
- 1-(2,3-dideoxy-2,3-didehydro-2-fluoro-4-thioribofuranosyl)cytosine [MeSH Supplementary Concept]
- 1-(2,3-dideoxy-2,3-difluoroarabinofuranosyl)cytosine [MeSH Supplementary Concept]
- 1-(2,3-dideoxy-2-fluoropentofuranosyl)-5-fluorocytosine [MeSH Supplementary Concept]
- 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine [MeSH Supplementary Concept]
- 1-(2,3-dideoxy-hexopyranosyl)cytosine [MeSH Supplementary Concept]
- 1-(2,5-dideoxy-beta-hexofuranosyl)cytosine [MeSH Supplementary Concept]
- 2',3'-didehydro-2',3'-dideoxy-N4 -hydroxy-5-fluorocytidine [MeSH Supplementary Concept]
- 2',3'-didehydro-2',3'-dideoxy-N4-hydroxycytidine [MeSH Supplementary Concept]
- 2',3'-dideoxy-2',3'-dehydro-5-fluorocytidine triphosphate [MeSH Supplementary Concept]
- 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine [MeSH Supplementary Concept]
- 2',3'-dideoxy-2',3'-methanocytidine [MeSH Supplementary Concept]
- 2',3'-dideoxy-5-fluorocytidine 5'-triphosphate [MeSH Supplementary Concept]
- 2',3'-dideoxy-5-methylcytidine [MeSH Supplementary Concept]
- 2',3'-dideoxy-beta-5-fluorocytidine [MeSH Supplementary Concept]
- 2',3'-dideoxycytidine monophosphate diglyceride [MeSH Supplementary Concept]
- 2',3'-dideoxycytidinene [MeSH Supplementary Concept]
- 3'-S-(2-Cyanoethyl-N,N-diisopropylphosphorothioamidite)- N4-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine [MeSH Supplementary Concept]
- 3'-amino-2',3'-dideoxycytidine [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxy-5-methylcytidine [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxycytidine [MeSH Supplementary Concept]
- 3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine [MeSH Supplementary Concept]
- 3'-thio-2',3'-dideoxycytidine [MeSH Supplementary Concept]
- 6-amino-3-(5-ethynyl-5-(hydroxymethyl)oxolan-2-yl)-3-hydroxypyrimidin-2-one [MeSH Supplementary Concept]
- N(4)-benzoyl-2',3'-dideoxy-2',3'-didehydrocytidine [MeSH Supplementary Concept]
- N4-((diisopropylamino)methylene)-2',3'-dideoxycytidine [MeSH Supplementary Concept]
- N4-((diisopropylamino)methylene)-3'-fluoro-2',3'-dideoxycytidine [MeSH Supplementary Concept]
- beta-D-4'-C-ethynyl-2',3'-dideoxycytidine [MeSH Supplementary Concept]
- dexelvucitabine [MeSH Supplementary Concept]
- racivir [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing zalcitabine (medicinal product) [SNOMED CT concept]
- Zalcitabine [ICD-11 Extension code]
- Zalcitabine [NCIt concept]
- Zalcitabine [LOINC component]
- Zalcitabine (substance) [SNOMED CT concept]
- zalcitabine [ATC Code]
- zalcitabine [SNOMED Notion]
Validated automatic mappings to BTNT
- zalcitabine [ATC Code]

Keyword's position in hierarchy(ies) :

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