Double Minutes

Preferred Label : Double Minutes;

NCIt synonyms : DM; Double Minute Chromosome;

NCIt definition : An extrachromosomal circular DNA located in the nucleus that is relatively small in size and contains chromatin but lacks a centromere and telomeres. These circular DNAs are found in tumor cells and are able to replicate during cell division during chromosome replication. They often contain extra copies of oncogenes and/or genes involved in drug resistance and lack transcription regulatory elements. Unregulated expression of genes present in these structures may play a role in tumor growth and tumor cell survival.;

Details

Origin ID

C6833;

UMLS CUI

C1512047;

Automatic exact mappings (from CISMeF team)
- DM1 protein kinase [ORDO Gene]
- Decimeter (qualifier value) [SNOMED CT concept]
- Double minute chromosome [PASCAL descriptor]
- dermatomyositis [MeSH Descriptor]
- diabetes [MedlinePlus Topic]
False automatic mappings
- Dermatomyositis [ORDO Disease]
- Myotonic dystrophy 1 [OMIM Phenotype]
Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
may_be_cytogenetic_abnormality_of_disease
- Abdominal Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Adult Anaplastic Oligodendroglioma [NCIt concept]
- Adult Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Advanced Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Anaplastic Oligodendroglioma [NCIt concept]
- Anaplastic Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted [NCIt concept]
- Anaplastic Oligodendroglioma, Not Otherwise Specified [NCIt concept]
- Cardiac Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Central Nervous System Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Childhood Anaplastic Oligodendroglioma [NCIt concept]
- Childhood Conventional Osteosarcoma [NCIt concept]
- Childhood Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Chondroblastic Osteosarcoma [NCIt concept]
- Classic Medulloblastoma [NCIt concept]
- Conventional Osteosarcoma [NCIt concept]
- Fibroblastic Osteosarcoma [NCIt concept]
- Frontal Lobe Anaplastic Oligodendroglioma [NCIt concept]
- Giant Cell-Rich Osteosarcoma [NCIt concept]
- Head and Neck Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Locally Advanced Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Metastatic Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Osteoblastic Osteosarcoma [NCIt concept]
- Penile Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Prostate Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Recurrent Anaplastic Oligodendroglioma [NCIt concept]
- Recurrent Childhood Anaplastic Oligodendroglioma [NCIt concept]
- Recurrent Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Refractory Anaplastic Oligodendroglioma [NCIt concept]
- Refractory Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Resectable Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Retroperitoneal Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Sinonasal Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Skin Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Undifferentiated Pleomorphic Sarcoma [NCIt concept]
- Undifferentiated Pleomorphic Sarcoma with Osteoclast-Like Giant Cells [NCIt concept]
- Undifferentiated Pleomorphic Sarcoma, Inflammatory Variant [NCIt concept]
- Unresectable Undifferentiated Pleomorphic Sarcoma [NCIt concept]

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