Giant Cell-Rich Osteosarcoma

Preferred Label : Giant Cell-Rich Osteosarcoma;

NCIt synonyms : GCRO;

NCIt related terms : Giant Cell Rich Osteosarcoma;

NCIt definition : An exceedingly rare, high-grade variant of conventional osteosarcoma characterized by the presence of numerous osteoclast-like giant cells and variable amount of tumor osteoid.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1662218;

Details

Origin ID

C179410;

UMLS CUI

C5555667;

Disease excludes normal cell origin
- Bone Marrow Stem Cell [NCIt concept]
- Epithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
Disease may have findings
- Lytic Bone Lesion [NCIt concept]
- Osteosclerotic Lesion [NCIt concept]
- Pain [NCIt concept]
- Pathologic Fracture [NCIt concept]
Excludes anatomical site(s)
- Soft Tissue [NCIt concept]
Has associated anatomic sites
- Bone [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
- Musculoskeletal System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- OS Authorized Value Terminology [NCIt concept]
- OS Histology Table [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Intermediate Filaments Present [NCIt concept]
- Intracytoplasmic Eosinophilic Inclusion [NCIt concept]
disease_excludes_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Connective and Soft Tissue Cell [NCIt concept]
- Malignant Osteoblast [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Connective and Soft Tissue Cell [NCIt concept]
- Neoplastic Osteoblast [NCIt concept]
- Osteoclast-Like Giant Cell [NCIt concept]
disease_has_finding
- Cellular Pleomorphism [NCIt concept]
- High Grade Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Osseous Differentiation [NCIt concept]
- Osteoid Formation [NCIt concept]
- Primary Lesion [NCIt concept]
- Vascular Channel Formation [NCIt concept]
disease_has_grade
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Connective and Soft Tissue Cell [NCIt concept]
- Osteoblast [NCIt concept]
disease_has_normal_tissue_origin
- Bone Tissue [NCIt concept]
- Connective Tissue [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
- Medullary Bone [NCIt concept]
disease_has_primary_anatomic_site
- Bone [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Double Minutes [NCIt concept]
- Gain of Chromosome 1 [NCIt concept]
- Homogeneously Staining Region [NCIt concept]
- Loss of Chromosome 10 [NCIt concept]
- Loss of Chromosome 13 [NCIt concept]
- Loss of Chromosome 6q [NCIt concept]
- Loss of Chromosome 9 [NCIt concept]
- del(13q14) [NCIt concept]
disease_may_have_molecular_abnormality
- FOS Gene Amplification [NCIt concept]
- RB1 Gene Inactivation [NCIt concept]

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