Childhood Conventional Osteosarcoma

Preferred Label : Childhood Conventional Osteosarcoma;

NCIt synonyms : Childhood Intracortical Osteosarcoma;

NCIt definition : A high grade malignant bone-forming mesenchymal neoplasm that produces osteoid and occurs in childhood. It arises from the medullary portion of the bone. It affects the long bones, and most commonly, the distal femur, proximal tibia, and proximal humerus. Pain with or without a palpable mass is the most common clinical presentation. It usually has an aggressive growth and may metastasize through the hematogenous route. The lung is the most frequent site of metastasis.;

Alternative definition : NICHD: A conventional osteosarcoma occurring during childhood.;

Neoplastic status : Malignant;

Details

Origin ID

C6590;

UMLS CUI

C1332974;

Currated CISMeF NLP mapping
- childhood intracortical osteosarcoma [DO Concept]
DO Cross reference
- childhood intracortical osteosarcoma [DO Concept]
Disease excludes normal cell origin
- Bone Marrow Stem Cell [NCIt concept]
- Epithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
Disease may have findings
- Lytic Bone Lesion [NCIt concept]
- Osteosclerotic Lesion [NCIt concept]
- Pain [NCIt concept]
- Pathologic Fracture [NCIt concept]
Excludes anatomical site(s)
- Soft Tissue [NCIt concept]
Has associated anatomic sites
- Bone [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
- Musculoskeletal System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- childhood intracortical osteosarcoma [DO Concept]
concept_is_in_subset
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Intermediate Filaments Present [NCIt concept]
- Intracytoplasmic Eosinophilic Inclusion [NCIt concept]
disease_excludes_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Connective and Soft Tissue Cell [NCIt concept]
- Malignant Osteoblast [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Connective and Soft Tissue Cell [NCIt concept]
- Neoplastic Osteoblast [NCIt concept]
disease_has_finding
- Anaplastic Lesion [NCIt concept]
- Cellular Pleomorphism [NCIt concept]
- Childhood Lesion [NCIt concept]
- High Grade Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Osseous Differentiation [NCIt concept]
- Osteoid Formation [NCIt concept]
- Primary Lesion [NCIt concept]
- Vascular Channel Formation [NCIt concept]
disease_has_grade
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Connective and Soft Tissue Cell [NCIt concept]
- Osteoblast [NCIt concept]
disease_has_normal_tissue_origin
- Bone Tissue [NCIt concept]
- Connective Tissue [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
- Medullary Bone [NCIt concept]
disease_has_primary_anatomic_site
- Bone [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Double Minutes [NCIt concept]
- Gain of Chromosome 1 [NCIt concept]
- Homogeneously Staining Region [NCIt concept]
- Loss of Chromosome 10 [NCIt concept]
- Loss of Chromosome 13 [NCIt concept]
- Loss of Chromosome 6q [NCIt concept]
- Loss of Chromosome 9 [NCIt concept]
- del(13q14) [NCIt concept]
disease_may_have_molecular_abnormality
- FOS Gene Amplification [NCIt concept]
- RB1 Gene Inactivation [NCIt concept]

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