NCIt definition : The hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with
potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase
I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation
of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded
DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication
machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase
I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of small cell lung cancer and
other types of cancer. It blocks certain enzymes needed for cell division and DNA
repair, and it may kill cancer cells. It is a type of camptothecin analog and a type
of topoisomerase inhibitor.;
UNII : 01DZ4127G7;
InChIKey : SJKBXKKZBKCHET-UQIIZPHYSA-N;
CAS number : 213819-48-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 213819-48-8
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