" /> Belotecan - CISMeF





Preferred Label : Belotecan;

NCIt definition : A semi-synthetic camptothecin analogue, with potential antitumor activity. Upon administration, belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.;

Alternative definition : NCI-GLOSS: The active ingredient in a substance being studied in the treatment of small cell lung cancer and other types of cancer. It blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of camptothecin analog and a type of topoisomerase inhibitor.;

UNII : 27Z82M2G1N;

InChIKey : LNHWXBUNXOXMRL-VWLOTQADSA-N;

CAS number : 256411-32-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 256411-32-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CKD-602;

Chemical formula : C25H27N3O4;

Codes from synonyms : CDR0000630915; 64;

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29/05/2024


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