Lenvatinib Mesylate

Preferred Label : Lenvatinib Mesylate;

NCIt synonyms : E7080 Mesylate; 6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]- 7-methoxy-, methanesulfonate (1:1); 4-[3-Chloro-4-(N'-cyclopropylureido)phenoxy]7-methoxyquinoline-6-carboxamide Mesylate; Multi-Kinase Inhibitor E7080 Mesylate; E7080;

NCIt definition : A synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. E7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.;

UNII : 3J78384F61;

InChIKey : HWLFIUUAYLEFCT-UHFFFAOYSA-N;

CAS number : 857890-39-2;

Drug name : Lenvima;

Chemical formula : C21H19ClN4O4.CH4O3S;

PubMed : 18765537;

Détails

Origin ID

C48636;

UMLS CUI

C2987642;

Automatic exact mappings (from CISMeF team)
- Lenvima [MeSH concept]
- lenvatinib [MeSH Supplementary Concept]
Manual NTBT mappings (CISMeF)
- Lenvatinib (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lenvatinib mesilate (substance) [SNOMED CT concept]
- lenvatinib [Substance BNPC]
Validated automatic mappings to NTBT
- lenvatinib [Substance BNPC]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Lenvatinib [NCIt concept]
has_target
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Everolimus/Lenvatinib Regimen [NCIt concept]
- Lenvatinib/Pembrolizumab Regimen [NCIt concept]
is_salt_form_of
- Lenvatinib [NCIt concept]

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