Lenvatinib - CISMeF

Preferred Label : Lenvatinib;

NCIt synonyms : Multi-Kinase Inhibitor E7080; 6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]- 7-methoxy-;

NCIt definition : A synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. Lenvatinib blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.;

UNII : EE083865G2;

InChIKey : WOSKHXYHFSIKNG-UHFFFAOYSA-N;

CAS number : 417716-92-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 417716-92-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ER-203492-00; E7080;

Chemical formula : C21H19ClN4O4;

Codes from synonyms : 301;

PubMed : 18765537;

Details

Origin ID

C95124;

UMLS CUI

C2986924;

Automatic exact mappings (from CISMeF team)
- Lenvatinib [ICD-11 Extension code]
- lenvatinib [ATC Code]
CISMeF manual mappings
- Lenvatinib (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- lenvatinib [MeSH concept]
- lenvatinib [MeSH Supplementary Concept]
- lenvatinib [Substance BNPC]
See also inter- (CISMeF)
- Product containing lenvatinib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lenvatinib (substance) [SNOMED CT concept]
- Product containing lenvatinib (medicinal product) [SNOMED CT concept]
- lenvatinib [MeSH concept]
- lenvatinib [MeSH Supplementary Concept]
- lenvatinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Lenvatinib Mesylate [NCIt concept]
has_target
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Lenvatinib Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Lenvatinib Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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