Epigenetic Silencing

Preferred Label : Epigenetic Silencing;

NCIt definition : This process is initiated by the formation of heterochromatin which ultimately leads to transcriptional inactivation or silencing. Once formed, heterochromatin can be inherited through many cell divisions, including meiosis. Inappropriate gain of heterochromatin structure, such as the inactivation of tumor suppressor genes by DNA hyper-methylation at their promoter regions, can be directly linked to carcinogenesis.;

Details

Origin ID

C48186;

UMLS CUI

C1707931;

Semantic type(s)
- Genetic Function [UMLS semantic type]
biological_process_involves_gene_product
- CDKN2B Antisense RNA 1 [NCIt concept]
- Core Histone Macro-H2A.2 [NCIt concept]
- Eukaryotic Translation Initiation Factor 6 [NCIt concept]
- Histone H3.1 [NCIt concept]
- Histone H3.2 [NCIt concept]
- NAD-Dependent Protein Deacetylase Sirtuin-1 [NCIt concept]
- Polycomb-Group Protein [NCIt concept]
- Pumilio Homolog 2 [NCIt concept]
process_includes_biological_process
- Hypermethylation [NCIt concept]
process_involves_gene
- CDKN2B-AS1 Gene [NCIt concept]
- CDKN2B-AS1 wt Allele [NCIt concept]
- EIF6 Gene [NCIt concept]
- EIF6 wt Allele [NCIt concept]
- H3C1 Gene [NCIt concept]
- H3C1 wt Allele [NCIt concept]
- H3C10 Gene [NCIt concept]
- H3C10 wt Allele [NCIt concept]
- H3C11 Gene [NCIt concept]
- H3C11 wt Allele [NCIt concept]
- H3C12 Gene [NCIt concept]
- H3C12 wt Allele [NCIt concept]
- H3C13 Gene [NCIt concept]
- H3C13 wt Allele [NCIt concept]
- H3C14 Gene [NCIt concept]
- H3C14 wt Allele [NCIt concept]
- H3C15 Gene [NCIt concept]
- H3C15 wt Allele [NCIt concept]
- H3C2 Gene [NCIt concept]
- H3C2 wt Allele [NCIt concept]
- H3C3 Gene [NCIt concept]
- H3C3 wt Allele [NCIt concept]
- H3C4 Gene [NCIt concept]
- H3C4 wt Allele [NCIt concept]
- H3C6 Gene [NCIt concept]
- H3C6 wt Allele [NCIt concept]
- H3C7 Gene [NCIt concept]
- H3C7 wt Allele [NCIt concept]
- H3C8 Gene [NCIt concept]
- H3C8 wt Allele [NCIt concept]
- MACROH2A2 Gene [NCIt concept]
- MACROH2A2 wt Allele [NCIt concept]
- PUM2 Gene [NCIt concept]
- PUM2 wt Allele [NCIt concept]
- SIRT1 Gene [NCIt concept]
- SIRT1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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