Pumilio Homolog 2

Preferred Label : Pumilio Homolog 2;

NCIt synonyms : Pumilio-2; PUM2;

NCIt definition : Pumilio homolog 2 (1066 aa, 114 kDa) is encoded by the human PUM2 gene. This protein is involved in mRNA binding and post-transcriptional repression of gene expression.;

NCIt note : Pumilio homolog 2 binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3'. (UniProt);

Details

Origin ID

C184966;

UMLS CUI

C1174252;

OMIM relation
- Pumilio rna binding family member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PUM2 protein, human [MeSH Supplementary Concept]
- PUM2 protein, human [MeSH concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- PUM2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- RNA Recognition Motif [NCIt concept]
gene_product_plays_role_in_biological_process
- Epigenetic Silencing [NCIt concept]
- Ligand Binding [NCIt concept]
- Post-Transcriptional Regulation [NCIt concept]
- RNA Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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