NCIt synonyms : SIR2; SIR2L1; Sirtuin (Silent Mating Type Information Regulation 2, S. cerevisiae, Homolog) 1 Gene; HST2, S. cerevisiae, Homolog of Gene; SIR2, S. cerevisiae, Homolog-Like 1 Gene; Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 1 (S. cerevisiae) Gene; Sirtuin 1 wt Allele; SIR2-ALPHA; SIR2alpha;
NCIt definition : Human SIRT1 wild-type allele is located in the vicinity of 10q21.3 and is approximately
34 kb in length. This allele, which encodes NAD-dependent protein deacetylase sirtuin-1
protein, may play a role in the attenuation of protein acetylation. Genetic variation
may be associated with the relapse of acute lymphoblastic leukemia.;
OMIM relation