N-Glycan Biosynthesis Pathway

Preferred Label : N-Glycan Biosynthesis Pathway;

NCIt synonyms : Glycoprotein Biosynthesis Pathway;

NCIt related terms : N-Glycan Biosynthesis; Glycoprotein Biosynthesis;

Alternative definition : KEGG: N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1-Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1-PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases, the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation.;

KEGG ID : hsa00510;

Details

Origin ID

C38819;

UMLS CUI

C0596625;

Automatic exact mappings (from CISMeF team)
- glycoprotein biosynthetic process [GO term]
- protein N-linked glycosylation [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase C [NCIt concept]
- Beta-1,4-Galactosyltransferase 1 [NCIt concept]
- Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol Alpha-1,3-Mannosyltransferase [NCIt concept]
- Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-Mannosyltransferase [NCIt concept]
- Dolichol-Phosphate Mannosyltransferase Subunit 1 [NCIt concept]
- Dolichyl Pyrophosphate Man9GlcNAc2 Alpha-1,3-Glucosyltransferase [NCIt concept]
- Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase Subunit 1 [NCIt concept]
- Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase Subunit DAD1 [NCIt concept]
- GDP-Fucose Transporter 1 [NCIt concept]
- Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha [NCIt concept]
- Putative Bifunctional UDP-N-Acetylglucosamine Transferase and Deubiquitinase ALG13 [NCIt concept]
- Tumor Suppressor Candidate 3 [NCIt concept]
- UDP-N-Acetylglucosamine-Dolichyl-Phosphate N-Acetylglucosaminephosphotransferase 1 [NCIt concept]
pathway_has_gene_element
- ALG12 wt Allele [NCIt concept]
- ALG13 wt Allele [NCIt concept]
- ALG3 wt Allele [NCIt concept]
- ALG6 wt Allele [NCIt concept]
- B4GALT1 wt Allele [NCIt concept]
- DAD1 wt Allele [NCIt concept]
- DPAGT1 wt Allele [NCIt concept]
- DPM1 wt Allele [NCIt concept]
- FNTA wt Allele [NCIt concept]
- MGAT4C wt Allele [NCIt concept]
- RPN1 wt Allele [NCIt concept]
- SLC35C1 wt Allele [NCIt concept]
- TUSC3 wt Allele [NCIt concept]

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