Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha

Preferred Label : Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha;

NCIt synonyms : PGGT1A; FPTA; CAAX Box Farnesyltransferase Alpha; FNTA; Type I Protein Geranyl-Geranyltransferase Alpha Subunit; RAS Proteins Prenyltransferase Alpha; FTase-Alpha; Protein Farnesyltransferase Type I Alpha Subunit; Protein Farnesyltransferase/Geranylgeranyltransferase Type I Alpha Subunit; GGTase-I-Alpha; Farnesyl-Protein Transferase Alpha-Subunit; CAAX-Farnesyltransferase Alpha-Subunit; CAAX Box Farnesyltransferase Alpha Subunit; EC 2.5.1.58; EC 2.5.1.59; CAAX Farnesyltransferase Subunit Alpha; Protein Prenyltransferase Alpha Subunit Repeat Containing 2; Ras Proteins Prenyltransferase Subunit Alpha; Type I Protein Geranyl-Geranyltransferase Subunit Alpha;

NCIt definition : Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (379 aa, 44 kDa) is encoded by the human FNTA gene. This protein is involved in protein prenylation.;

NCIt note : Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha forms a complex with either protein farnesyltransferase subunit beta or geranylgeranyl transferase type-1 subunit beta. The beta subunit confers the substrate specificity for the enzyme complex activity.;

Détails

Origin ID

C38601;

UMLS CUI

C1511395;

OMIM relation
- Farnesyltransferase, caax box, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- FNTA protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- FNTA Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- N-Glycan Biosynthesis Pathway [NCIt concept]
- Terpenoid Biosynthesis Pathway [NCIt concept]
- Ubiquinone Biosynthesis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Farnesyl Protein Transferase [NCIt concept]
- Geranylgeranyl Transferase [NCIt concept]
gene_product_plays_role_in_biological_process
- Isoprenylation Process [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

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