Ubiquinone Biosynthesis Pathway

Preferred Label : Ubiquinone Biosynthesis Pathway;

NCIt related terms : Ubiquinone Biosynthesis; Ubiquinone and other terpenoid-quinone biosynthesis; Ubiquinone and menaquinone biosynthesis;

Alternative definition : KEGG: Ubiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from the shikimate pathway; 4-hydroxybenzoate is directly formed from chorismate in bacteria, while it can be formed from either chorismate or tyrosine in yeast. The following biosynthesis of terpenoid moiety involves reactions of prenylation, decarboxylation, and three hydroxylations alternating with three methylations. The order of these reactions are somewhat different between bacteria and yeast. Phylloquinone (vitamin K1), menaquinone (vitamin K2), and tocopherol (vitamin E) are fat-soluble vitamins. Phylloquinone is a compound present in all photosynthetic plants serving as a cofactor for photosystem I-mediated electron transport. Menaquinone is an obligatory component of the electron-transfer pathway in bacteria.;

KEGG ID : hsa00130;

Details

Origin ID

C38880;

UMLS CUI

C1157248;

Automatic exact mappings (from CISMeF team)
- ubiquinone biosynthetic process [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- ubiquinone biosynthetic process [GO term]
has_gene_product_element
- 4-Hydroxybenzoate Polyprenyltransferase, Mitochondrial [NCIt concept]
- 4-Hydroxyphenylpyruvate Dioxygenase [NCIt concept]
- NAD(P)H Dehydrogenase [Quinone] 1 [NCIt concept]
- Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha [NCIt concept]
- Tyrosine Aminotransferase [NCIt concept]
- Ubiquinone Biosynthesis Monooxygenase COQ6, Mitochondrial [NCIt concept]
pathway_has_gene_element
- COQ2 wt Allele [NCIt concept]
- COQ6 wt Allele [NCIt concept]
- FNTA wt Allele [NCIt concept]
- HPD wt Allele [NCIt concept]
- NQO1 wt Allele [NCIt concept]
- TAT wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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