" /> NQO1 wt Allele - CISMeF





Preferred Label : NQO1 wt Allele;

NCIt synonyms : NMOR1; DTD; DHQU; NMORI; QR1; NAD(P)H Dehydrogenase, Quinone 1 wt Allele; DIA4;

NCIt definition : Human NQO1 wild-type allele is located in the vicinity of 16q22.1 and is approximately 17 kb in length. This allele, which encodes NAD(P)H dehydrogenase [quinone] 1 protein, plays a role in the reduction of quinones to hydroquinones. It is also involved in the biosynthesis of prothrombin. The NQO1 gene is overexpressed in many types of cancer.;

NCIt note : Benzene metabolites induce NQO1 gene expression. However, individuals homozygous for a certain allelic variant of this gene do not express NAD(P)H dehydrogenase [quinone] 1 protein and are susceptible to benzene-induced hematotoxicity. Allelic variants of the NQO1 gene which encode a protein product with diminished or abolished enzymatic activity are associated with a decreased risk for the development of lung cancer.;

GenBank Accession Number : NM_000903;

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11/05/2024


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