Farnesyl Protein Transferase

Preferred Label : Farnesyl Protein Transferase;

NCIt synonyms : Farnesyltransferase; Farnesyl Transferase; Protein Farnesyltransferase;

NCIt definition : A heterodimeric enzyme (alpha and beta subunits) that catalyzes the addition of farnesyl groups, as farnesyl diphosphate, to the C termini of proteins.;

NCIt note : Farnesyltransferase is comprised of protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha complexed with protein farnesyltransferase subunit beta.;

Details

Origin ID

C17526;

UMLS CUI

C0138837;

Automatic exact mappings (from CISMeF team)
- Farnesyl-diphosphate farnesyltransferase (substance) [SNOMED CT concept]
- farnesyltranstransferase [MeSH concept]
- farnesyltranstransferase [MeSH Descriptor]
- p21(ras) farnesyl-protein transferase [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- protein farnesyltransferase [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- protein farnesyltransferase [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_affected_by_chemical_or_drug
- BMS-214662 [NCIt concept]
- Perillyl Alcohol [NCIt concept]
- Tipifarnib [NCIt concept]
has_gene_product_element
- Protein Farnesyltransferase Subunit Beta [NCIt concept]
- Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha [NCIt concept]
is_target
- Antroquinonol Capsule [NCIt concept]
- BMS-214662 [NCIt concept]
- Farnesyl Transferase Inhibitor KO-2806 [NCIt concept]
- Lonafarnib [NCIt concept]
- Perillyl Alcohol [NCIt concept]
- Tipifarnib [NCIt concept]

Keyword's position in hierarchy(ies) :

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