Preferred Label : Antroquinonol Capsule;
NCIt related terms : ANTROQUINONOL;
NCIt definition : An orally available capsule containing antroquinonol, a farnesylated quinone derivative
isolated from the mycelium of Antrodia camphorata, with potential antineoplastic activity.
Upon oral administration, antroquinonol binds to and inhibits protein prenylation
mediated by the enzymes farnesyltransferase (FTase) and geranylgeranyltransferase
1 (GGTase-1). This prevents both post-translational prenylation and signaling activity
of a number of Ras superfamily proteins, such as Ras and Rho. This results in the
inhibition of downstream signaling, such as the PI3K/mTOR signaling pathway, and induces
apoptosis in susceptible tumor cells. Ras superfamily proteins are overexpressed in
numerous cancer cell types, and play a key role in tumor cell proliferation and survival.;
UNII : AX9P92T7JZ;
CAS number : 1010081-09-0;
Drug name : Hocena;
NCI Metathesaurus CUI : CL421596;
Origin ID : C119701;
UMLS CUI : C3900021;
Semantic type(s)
- concept_is_in_subset
- has_target
