Preferred Label : Lonafarnib;
NCIt synonyms : 4-[2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide;
NCIt related terms : SCH-66336; SCH 66336; 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide;
NCIt definition : A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib
binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational
modification and activation of Ras proteins. Ras proteins participate in numerous
signalling pathways (proliferation, cytoskeletal organization), and play an important
role in oncogenesis. Mutated ras proteins have been found in a wide range of human
cancers. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called enzyme inhibitors.;
UNII : IOW153004F;
InChIKey : DHMTURDWPRKSOA-RUZDIDTESA-N;
CAS number : 193275-84-2;
Drug name : Sarasar;
Molecule name : SCH-66336; SCH 66336;
Chemical formula : C27H31Br2ClN4O2;
NSC code : 719467;
Codes from synonyms : NSC0719467; 50354; CDR0000277243; CDR0000046699;
Origin ID : C1829;
UMLS CUI : C1257385;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
