Preferred Label : Farnesyl Transferase Inhibitor KO-2806;
NCIt synonyms : FTI KO-2806;
NCIt definition : An orally bioavailable inhibitor of farnesyl transferase, with potential antineoplastic
activity. Upon oral administration, farnesyl transferase inhibitor (FTI) KO-2806 targets,
binds to and inhibits the enzyme farnesyl transferase. By inhibiting the farnesylation
of proteins, this agent prevents the activation of Ras oncogenes, inhibits Ras-dependent
signaling and inhibits the proliferation of tumor cells in which Ras is overexpressed
and/or mutated. Ras plays an important role in cell signaling, division and differentiation.
Mutations of Ras may induce constitutive signal transduction leading to tumor cell
growth, proliferation, invasion, and metastasis.;
Molecule name : KO-2806; KO 2806;
NCI Metathesaurus CUI : CL1920795;
Origin ID : C201577;
UMLS CUI : C5907911;
Semantic type(s)
- concept_is_in_subset
- has_target
