Preferred Label : Darlifarnib;
NCIt synonyms : FTI KO-2806; Farnesyl Transferase Inhibitor KO-2806;
NCIt definition : An orally bioavailable inhibitor of farnesyl transferase, with potential antineoplastic
activity. Upon oral administration, darlifarnib targets, binds to and inhibits the
enzyme farnesyl transferase. By inhibiting the farnesylation of proteins, this agent
prevents the activation of Ras oncogenes, inhibits Ras-dependent signaling and inhibits
the proliferation of tumor cells in which Ras is overexpressed and/or mutated. Ras
plays an important role in cell signaling, division and differentiation. Mutations
of Ras may induce constitutive signal transduction leading to tumor cell growth, proliferation,
invasion, and metastasis.;
UNII : 9PE5MSX2YS;
CAS number : 3065226-39-0;
Molecule name : KO-2806; KO 2806;
NCI Metathesaurus CUI : CL1920795;
Origin ID : C201577;
UMLS CUI : C5907911;
Semantic type(s)
- concept_is_in_subset
- has_target
