" /> Darlifarnib - CISMeF





Preferred Label : Darlifarnib;

NCIt synonyms : FTI KO-2806; Farnesyl Transferase Inhibitor KO-2806;

NCIt definition : An orally bioavailable inhibitor of farnesyl transferase, with potential antineoplastic activity. Upon oral administration, darlifarnib targets, binds to and inhibits the enzyme farnesyl transferase. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits Ras-dependent signaling and inhibits the proliferation of tumor cells in which Ras is overexpressed and/or mutated. Ras plays an important role in cell signaling, division and differentiation. Mutations of Ras may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.;

UNII : 9PE5MSX2YS;

CAS number : 3065226-39-0;

Molecule name : KO-2806; KO 2806;

NCI Metathesaurus CUI : CL1920795;

Détails


Vous pouvez consulter :


Nous contacter.
24/07/2025


[Accueil] [Haut de page]

© CHU de Rouen. Toute utilisation partielle ou totale de ce document doit mentionner la source.