" /> BMS-214662 - CISMeF





Preferred Label : BMS-214662;

NCIt synonyms : FTI BMS 214662; 7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine; BMS214662;

NCIt definition : A nonsedating benzodiazepine derivative with potential antineoplastic activity. Farnesyltransferase inhibitor BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. This agent may reverse the malignant phenotype of H-Ras-transformed cells and has been shown to be active against tumor cells with and without Ras mutations.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors.;

UNII : L2U9GFD244;

InChIKey : OLCWFLWEHWLBTO-HSZRJFAPSA-N;

CAS number : 195987-41-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 195987-41-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BMS-214662;

NSC code : 710086;

Codes from synonyms : CDR0000044889;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
14/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.