Glutamate-Cysteine Ligase Catalytic Subunit

Preferred Label : Glutamate-Cysteine Ligase Catalytic Subunit;

NCIt synonyms : GCS; GCS Heavy Chain; GLCL; GLCLC; Gamma-Glutamylcysteine Synthetase, Catalytic Subunit; GCLC; Gamma-ECS; Gamma-Glutamylcysteine Synthetase; Gamma-Glutamylcysteine Synthetase Catalytic Subunit; Glutamate--Cysteine Ligase Catalytic Subunit; EC 6.3.2.2;

NCIt definition : Glutamate-cysteine ligase catalytic subunit (637 aa, 73 kDa) is encoded by the human GCLC gene. This protein is involved in the biosynthesis of glutathione.;

NCIt note : Protein_Plays_Role_In_Biological_Process: Glutathione Biosynthesis;

Détails

Origin ID

C38608;

UMLS CUI

C1522376;

Automatic exact mappings (from CISMeF team)
- Gamma glutamyl cysteine synthetase [LOINC component]
- Glasgow coma scale (assessment scale) [SNOMED CT concept]
- Glutamate-cysteine ligase (substance) [SNOMED CT concept]
- Glutamate-cysteine ligase, catalytic subunit [OMIM gene]
- Group-specific component [OMIM Phenotype]
- Udp-glucose ceramide glucosyltransferase [OMIM gene]
- glasgow coma scale [MeSH Descriptor]
- glutamate-cysteine ligase [MeSH Descriptor]
- glutamate-cysteine ligase catalytic subunit [HGNC gene]
- glutamate-cysteine ligase catalytic subunit [ORDO Gene]
- glutamate-cysteine ligase modifier subunit [HGNC gene]
OMIM relation
- Glutamate-cysteine ligase, catalytic subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- GCLC protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GCLC Gene [NCIt concept]
- Ligase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alanine, Aspartate and Glutamate Metabolism Pathway [NCIt concept]
- Glutathione Metabolism Pathway [NCIt concept]
gene_product_is_physical_part_of
- Gamma-Glutamylcysteine Synthetase [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Peptide Metabolism [NCIt concept]
is_target
- Buthionine Sulfoximine [NCIt concept]

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