Gamma-Glutamylcysteine Synthetase

Preferred Label : Gamma-Glutamylcysteine Synthetase;

NCIt synonyms : Glutamate-Cysteine Ligase; EC 6.3.2.2; Gamma-Glutamylcysteinyl Synthetase;

NCIt definition : Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. (LocusLink);

Details

Origin ID

C16602;

UMLS CUI

C0017037;

Currated CISMeF NLP mapping
- glutamate-cysteine ligase [SNOMED Notion]
False automatic mappings
- Glutamate-cysteine ligase (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Gamma glutamyl cysteine synthetase [LOINC component]
- Glutamate-Cysteine ligase [MeSH concept]
- Glutamate-cysteine ligase (substance) [SNOMED CT concept]
- glutamate-cysteine ligase [SNOMED Notion]
- glutamate-cysteine ligase [MeSH Descriptor]
gene_product_affected_by_chemical_or_drug
- Buthionine Sulfoximine [NCIt concept]
gene_product_has_biochemical_function
- Ligase [NCIt concept]
has_gene_product_element
- Glutamate-Cysteine Ligase Catalytic Subunit [NCIt concept]
- Glutamate-Cysteine Ligase Regulatory Subunit [NCIt concept]

Keyword's position in hierarchy(ies) :

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