" /> Buthionine Sulfoximine - CISMeF





Preferred Label : Buthionine Sulfoximine;

NCIt synonyms : Buthionine Sulphoximine; 2-Amino-4-(S-butylsulfonimidoyl) Butanoic Acid; L-Buthionine Sulfoximine; S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine; S-(n-Butyl)homocysteine Sulfoximine; BSO;

NCIt related terms : BUTHIONINE SULFOXIMINE, L-; Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-;

NCIt definition : A synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a metabolite that plays a critical role in protecting cells against oxidative stress, and resulting in free radical-induced apoptosis. Elevated glutathione levels are associated with tumor cell resistance to alkylating agents and platinum compounds. By depleting cells of glutathione, this agent may enhance the in vitro and in vivo cytotoxicities of various chemotherapeutic agents in drug-resistant tumors. Buthionine sulfoximine may also exhibit antiangiogenesis activity. (NCI04);

Alternative definition : NCI-GLOSS: A drug that may help prevent resistance to some anticancer drugs.;

UNII : EEY8DZS103;

InChIKey : KJQFBVYMGADDTQ-CVSPRKDYSA-N;

CAS number : 83730-53-4;

Chemical formula : C8H18N2O3S;

NSC code : 326231;

Codes from synonyms : 30363; NSC0326231; CDR0000045163;

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07/05/2025


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