buthionine sulfoximine

Preferred Label : buthionine sulfoximine;

MeSH definition : A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7);

MeSH synonym : sulfoximine, buthionine;

MeSH CAS label : butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-;

Registry Number MeSH : 5072-26-4;

Is substance : O;

Details

Origin ID

D019328;

UMLS CUI

C0054252;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Buthionine Sulfoximine [NCIt concept]
Pharmacological action(s)
- antimetabolites, antineoplastic [MeSH Descriptor]
- enzyme inhibitors [MeSH Descriptor]
- radiation-protective agents [MeSH Descriptor]
- radiation-sensitizing agents [MeSH Descriptor]
Record concept(s)
- buthionine sulfoximine [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hazardous or Poisonous Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Buthionine Sulfoximine [NCIt concept]

Keyword's position in hierarchy(ies) :

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