glutamate-cysteine ligase

Preferred Label : glutamate-cysteine ligase;

MeSH definition : One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.;

MeSH synonym : gamma-glutamyl-cysteine synthetase; glutamylcysteine synthetase; ligase, glutamate-cysteine; synthetase, gamma-glutamyl-cysteine; gamma glutamyl cysteine synthetase; synthetase, glutamylcysteine; glutamate cysteine ligase;

MeSH CAS label : L-Glutamate:L-cysteine gamma-ligase (ADP-forming);

MeSH Related Number : 9023-64-7 (CAS RN);

Registry Number MeSH : EC 6.3.2.2;

Is substance : O;

UNII : EC 6.3.2.2;

Details

Origin ID

D005721;

UMLS CUI

C0017037;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- Glutamate-Cysteine ligase [MeSH concept]
Related MeSH Supplementary Concept(s)
- GCLC protein, human [MeSH Supplementary Concept]
- GCLC protein, rat [MeSH Supplementary Concept]
- GCLM protein, human [MeSH Supplementary Concept]
- GCLM protein, mouse [MeSH Supplementary Concept]
- GCLM protein, rat [MeSH Supplementary Concept]
- GSH1 protein, S cerevisiae [MeSH Supplementary Concept]
- Gamma-Glutamylcysteine synthetase deficiency, hemolytic anemia due to [MeSH Supplementary Concept]
- Gsh1 protein, arabidopsis [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Gamma glutamyl cysteine synthetase [LOINC component]
- Gamma-Glutamylcysteine Synthetase [NCIt concept]
- Glutamate-cysteine ligase (substance) [SNOMED CT concept]
- glutamate-cysteine ligase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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