PC4 and SFRS1-Interacting Protein Isoform 2

Preferred Label : PC4 and SFRS1-Interacting Protein Isoform 2;

NCIt synonyms : Transcriptional Coactivator p52; PAIP; PSIP2; PC4 and SFRS1 Interacting Protein 2; PSIP1; Transcriptional Coactivator-p52; p52;

NCIt definition : PC4 and SFRS1-interacting protein isoform 2 (333 aa, 38 kDa) is encoded by the human PSIP1 gene. This protein is involved in both transcriptional regulation and mRNA splicing.;

NCIt note : Transcriptional Coactivator p52 is an alternatively spliced product that shares a 325-aa region with Transcriptional Coactivator p75, but shows distinct coactivator properties. p52 interacts strongly with the VP16 activation domain and with components of the general transcriptional machinery. A potent broad-specificity coactivator, p52 interacts with transcriptional activators and general transcription factors, as well as with ASF/SF2 to modulate pre-mRNA splicing. Most p52 appears to be colocalized with ASF/SF2 in the nucleoplasm. p52 may coordinate pre-mRNA splicing and transcriptional activation of class II genes.;

Details

Origin ID

C34096;

UMLS CUI

C1615518;

OMIM relation
- Pc4- and sfrs1-interacting protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PSIP1 protein, human [MeSH concept]
- PSIP1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- PSIP1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Transcription Coactivator [NCIt concept]
gene_product_has_structural_domain_or_motif
- PWWP Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- RNA Splicing [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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