PC4 and SFRS1-Interacting Protein Isoform 1

Preferred Label : PC4 and SFRS1-Interacting Protein Isoform 1;

NCIt synonyms : DFS 70; PAIP; Lens Epithelium-Derived Growth Factor; Dense Fine Speckles 70 kDa Protein; Transcriptional Coactivator p75; PSIP1; PC4 and SFRS1 Interacting Protein 1; CLL-Associated Antigen KW-7; p75; Transcriptional Coactivator-p75;

NCIt definition : PC4 and SFRS1-interacting protein isoform 1 (530 aa, 60 kDa) is encoded by the human PSIP1 gene. This protein plays a role in transcriptional regulation, neurogenesis and HIV infection.;

NCIt note : Transcriptional Coactivator p75 is an alternatively spliced product that shares a 325-aa region with Transcriptional Coactivator p52, but shows distinct coactivator properties. p75 interacts strongly with the VP16 activation domain. p52 is a potent broad-specificity coactivator; p75 is less active for most activation domains.; PC4 and SFRS1-interacting protein isoform 1 is involved in stress responses and neuroepithelial stem cell differentiation, in particular in lens epithelial cell gene regulation. (UniProt);

Details

Origin ID

C34097;

UMLS CUI

C1615518;

Currated CISMeF NLP mapping
- lens epithelium-derived growth factor [MeSH concept]
- lens epithelium-derived growth factor [MeSH Supplementary Concept]
- p75(gag-fos-fox) [MeSH concept]
OMIM relation
- Pc4- and sfrs1-interacting protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PSIP1 protein, human [MeSH concept]
- PSIP1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- PSIP1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Transcription Coactivator [NCIt concept]
gene_product_has_structural_domain_or_motif
- PWWP Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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