Preferred Label : PWWP Domain;
NCIt definition : Around 70 amino acids and weakly conserved, the PWWP Domain is named after a conserved
Pro-Trp-Trp-Pro motif often found as multiple copies in proteins that contain chromatin-association
domains or in cell growth and differentiation transcription factors, such as WHSC1
(C-terminus) and ASH1/Trithorax Group proteins. Although its function is unknown,
the amino acid composition suggests that it may be involved in protein-protein interactions.
The domain N-terminal half resembles a barrel-like five-stranded structure; the C-terminal
half contains a five-helix bundle. The halves form a module that exhibits positive
electrostatic potential. Alone, the domain binds DNA in vitro, probably through its
basic surface. (NCI);
Origin ID : C14044;
UMLS CUI : C1518833;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
