Preferred Label : DNA (Cytosine-5)-Methyltransferase 3B;
NCIt synonyms : DNA (Cytosine-5-)-Methyltransferase 3B; EC 2.1.1.37; M.HsaIIIB; DNA Methyltransferase HsaIIIB; ICF; DNA (Cytosine-5-)-Methyltransferase 3 Beta; DNMT3B Protein; DNA MTase HsaIIIB; DNMT3B; DNA Methyltransferase 3B; DNA Methyltransferase-3B;
NCIt definition : DNA (cytosine-5)-methyltransferase 3B (853 aa, 96 kDa) is encoded by the human DNMT3B
gene. This protein is involved in DNA methylation.;
NCIt note : DNA (cytosine-5)-methyltransferase 3B is expressed as six isoforms (1, 2, 3, 4, 5
and 6) that are produced by alternative splicing. Isoforms 4 and 5 are probably not
functional due to the deletion of two conserved methyltransferase motifs. Isoform
1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous,
4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and
5 is detectable only in testis and at very low level in brain and prostate. (UniProt);
Origin ID : C26112;
UMLS CUI : C1452577;
OMIM relation
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
