Megakaryocyte-Associated Tyrosine-Protein Kinase

Preferred Label : Megakaryocyte-Associated Tyrosine-Protein Kinase;

NCIt synonyms : CSK-Homologous Kinase; Tyrosine Kinase MATK; Hydroxyaryl-Protein Kinase; Leukocyte Carboxyl-Terminal Src Kinase Related Protein; CHK; CTK; CSK-Type Protein Tyrosine Kinase; Hematopoietic Consensus Tyrosine-Lacking Kinase; LSK; Tyrosine-Protein Kinase CTK; Protein Kinase HYL; HYL; MATK; HYL Tyrosine Kinase; CSK Homologous Kinase; EC 2.7.10.2; Megakaryocyte-Associated Tyrosine Kinase;

NCIt definition : Megakaryocyte-associated tyrosine-protein kinase (507 aa, 56 kDa) is encoded by the human MATK gene. This protein is involved in cell proliferation and tyrosine phosphorylation.;

NCIt note : MATK may regulate SRC activity in brain by phosphorylating the C-terminal negative regulatory tyrosine. (UniProt);

Details

Origin ID

C33988;

UMLS CUI

C0250935;

OMIM relation
- Megakaryoctye-associated tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MATK protein, human [MeSH concept]
- MATK protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- MATK Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Neurotrophin Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Megakaryocyte Differentiation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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