Histone-Lysine N-Methyltransferase EZH2

Preferred Label : Histone-Lysine N-Methyltransferase EZH2;

NCIt synonyms : Enhancer of Zeste 2; Enhancer of Zeste Homolog 2; EZH2; ENX-1; EC 2.1.1.43; EZH1; Lysine N-Methyltransferase 6; Enhancer of Zeste Homolog 2 Protein; EC 2.1.1.356;

NCIt definition : Histone-lysine N-methyltransferase EZH2 (746 aa, 85 kDa) is encoded by the human EZH2 gene. This protein is involved in the regulation of chromatin modification.;

NCIt note : EZH2 appears to associate with embryonic ectoderm development protein VAV1 and with ATRX via the SET domain.;

Details

Origin ID

C30175;

UMLS CUI

C1172384;

OMIM relation
- Enhancer of zeste 2 polycomb repressive complex 2 subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- EZH2 protein, human [MeSH Supplementary Concept]
- EZH2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EZH2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
- DNA Binding Protein [NCIt concept]
- Polycomb-Group Protein [NCIt concept]
gene_product_has_gene_product_variant
- EZH2 NP_004447.2:p.Y646C [NCIt concept]
- EZH2 NP_004447.2:p.Y646D [NCIt concept]
- EZH2 NP_004447.2:p.Y646F [NCIt concept]
- EZH2 NP_004447.2:p.Y646H [NCIt concept]
- EZH2 NP_004447.2:p.Y646N [NCIt concept]
- EZH2 NP_004447.2:p.Y646S [NCIt concept]
- EZH2 NP_004447.2:p.Y646X [NCIt concept]
- EZH2 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Gene Silencing Pathway [NCIt concept]
gene_product_is_physical_part_of
- Polycomb Repressive Complex 2 [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]
- Transcriptional Repression [NCIt concept]
is_target
- EZH1/2 Inhibitor HH2853 [NCIt concept]
- EZH2 Inhibitor [NCIt concept]
- EZH2 Inhibitor PF-06821497 [NCIt concept]
- EZH2 Inhibitor SHR2554 [NCIt concept]
- Histone-Lysine N-Methyltransferase EZH2 Inhibitor GSK2816126 [NCIt concept]
- Lirametostat [NCIt concept]
- Tazemetostat [NCIt concept]
- Tazemetostat Hydrobromide [NCIt concept]
- Tulmimetostat [NCIt concept]
- Valemetostat [NCIt concept]
- Valemetostat Tosylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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