Polycomb Repressive Complex 2

Preferred Label : Polycomb Repressive Complex 2;

NCIt synonyms : PRC2;

NCIt definition : A protein complex that represses transcription by stimulating chromatin compaction through the trimethylation of lysine-27 of histone H3, which recruits Polycomb repressive complex 1. This complex is involved in embryonic development, X chromosome inactivation, maintenance of stem cell fate and imprinting.;

NCI Metathesaurus CUI : CL1663038;

Details

Origin ID

C180426;

UMLS CUI

C3494414;

Automatic exact mappings (from CISMeF team)
- polycomb repressive complex 2 [MeSH Descriptor]
- polycomb repressive complex 2 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- polycomb repressive complex 2 [MeSH Descriptor]
- polycomb repressive complex 2 [MeSH concept]
has_gene_product_element
- Histone-Binding Protein RBBP4 [NCIt concept]
- Histone-Binding Protein RBBP7 [NCIt concept]
- Histone-Lysine N-Methyltransferase EZH1 [NCIt concept]
- Histone-Lysine N-Methyltransferase EZH2 [NCIt concept]
- Polycomb Protein EED [NCIt concept]
- Polycomb Protein SUZ12 [NCIt concept]
is_target
- EED Inhibitor MAK683 [NCIt concept]
- PRC2 Inhibitor ORIC-944 [NCIt concept]

Keyword's position in hierarchy(ies) :

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