Histone-Lysine N-Methyltransferase EZH1

Preferred Label : Histone-Lysine N-Methyltransferase EZH1;

NCIt synonyms : EC 2.1.1.356; EZH1; ENX-2; Enhancer of Zeste Homolog 1;

NCIt definition : Histone-lysine N-methyltransferase EZH1 (747 aa, 85 kDa) is encoded by the human EZH1 gene. This protein plays a role in the formation of H3K27me1, H3K27me2 and H3K27me3;

Details

Origin ID

C180403;

UMLS CUI

C0534041;

Automatic exact mappings (from CISMeF team)
- Enhancer of zeste 1 polycomb repressive complex 2 subunit [OMIM gene]
- enhancer of zeste 2 polycomb repressive complex 2 subunit [ORDO Gene]
OMIM relation
- Enhancer of zeste 1 polycomb repressive complex 2 subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- EZH1 protein, human [MeSH Supplementary Concept]
- EZH1 protein, human [MeSH concept]
gene_encodes_gene_product
- EZH1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
- Polycomb-Group Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysine Degradation Pathway [NCIt concept]
gene_product_is_physical_part_of
- Polycomb Repressive Complex 2 [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]
- Transcriptional Repression [NCIt concept]
is_target
- EZH1/2 Inhibitor HH2853 [NCIt concept]
- Valemetostat [NCIt concept]
- Valemetostat Tosylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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