Preferred Label : Tazemetostat;
NCIt synonyms : N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(oxan-4-yl)amino)-4-methyl-4'-((morpholin-4-yl)methyl)(1,1'-biphenyl)-3-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide;
NCIt definition : An orally available, small molecule selective and S-adenosyl methionine (SAM) competitive
inhibitor of histone methyl transferase EZH2, with potential antineoplastic activity.
Upon oral administration, tazemetostat selectively inhibits the activity of both wild-type
and mutated forms of EZH2. Inhibition of EZH2 specifically prevents the methylation
of histone H3 lysine 27 (H3K27). This decrease in histone methylation alters gene
expression patterns associated with cancer pathways and results in decreased tumor
cell proliferation in EZH2 mutated cancer cells. EZH2, which belongs to the class
of histone methyltransferases (HMTs), is overexpressed or mutated in a variety of
cancer cells and plays a key role in tumor cell proliferation.;
UNII : Q40W93WPE1;
InChIKey : NSQSAUGJQHDYNO-UHFFFAOYSA-N;
CAS number : 1403254-99-8;
Molecule name : E 7438; EPZ-6438; E-7438; EPZ 6438;
Codes from synonyms : 54224;
Origin ID : C107506;
UMLS CUI : C4086895;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
