Preferred Label : Topotecan Hydrochloride;
NCIt synonyms : topotecan hydrochloride (oral); Hycamptamine; Topotecan HCl; (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino[1,2-b]
quinoline-3,14-(4H,12H)-dione Monohydrochloride; Nogitecan Hydrochloride;
NCIt related terms : Hycamtin;
NCIt definition : The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic
activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase
I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand
DNA breaks and producing potentially lethal double-strand DNA breaks when complexes
are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based
alkaloid extracted from the Asian tree Camptotheca acuminata.;
Alternative definition : NCI-GLOSS: A drug used to treat certain types of ovarian cancer, lung cancer, and
cervical cancer. Hycamtin is a type of topoisomerase inhibitor.;
UNII : 956S425ZCY;
InChIKey : DGHHQBMTXTWTJV-BQAIUKQQSA-N;
CAS number : 119413-54-6;
Drug name : Hycamtin; Potactasol; Evotopin; Topotec;
Molecule name : SKF S-104864-A; SKF S 104864 A;
Chemical formula : C23H23N3O5.HCl;
NSC code : 609699;
Codes from synonyms : NSC0609699; CDR0000410746; CDR0000507692;
Origin ID : C2828;
UMLS CUI : C0886549;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- Validated automatic mappings to NTBT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
