Preferred Label : Topotecan;
NCIt synonyms : Topotecan Lactone; Hycamptamine; 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin; (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione;
NCIt definition : A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid
extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase
I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase
of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand
DNA breaks and producing potentially lethal double-strand DNA breaks when encountered
by the DNA replication machinery.;
Alternative definition : NCI-GLOSS: A drug used to treat certain types of ovarian cancer, lung cancer, and
cervical cancer. Topotecan is a type of topoisomerase inhibitor.;
UNII : 7M7YKX2N15;
InChIKey : UCFGDBYHRUNTLO-QHCPKHFHSA-N;
CAS number : 123948-87-8;
Chemical formula : C23H23N3O5;
NSC code : 641007;
ChEBI ID : CHEBI:63632;
Codes from synonyms : NSC0641007; CDR0000045342; 503;
Origin ID : C1413;
UMLS CUI : C0146224;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
