Heterotrimeric G Protein

Preferred Label : Heterotrimeric G Protein;

NCIt definition : Heterotrimeric guanine nucleotide-binding proteins (G proteins) are signal transducers, attached to the cell surface plasma membrane, that connect receptors to effectors and thus to intracellular signaling pathways (1). Receptors that couple to G proteins communicate signals from a large number of hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. After the first four G proteins (Gs, Gt, Gi, and Go) were identified by biochemical purification, a large number of G proteins and their subunits were identified by cDNA cloning (2). G proteins consist of three subunits, alpha, beta, and gamma. When signaling, they function in essence as dimers because the signal is communicated either by the Ga subunit or the Gbg complex. In most cases, Gbg subunits cannot be dissociated under nondenaturing conditions. Currently there are 20 known G, 6 G, and 11 G subunits. (from Science 2002;296:1636-9);

Details

Origin ID

C18281;

UMLS CUI

C0752348;

Automatic exact mappings (from CISMeF team)
- heterotrimeric GTP-Binding proteins [MeSH concept]
- heterotrimeric GTP-Binding proteins [MeSH Descriptor]
Currated CISMeF NLP mapping
- obsolete heterotrimeric G-protein [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- heterotrimeric GTP-Binding proteins [MeSH concept]
- heterotrimeric GTP-Binding proteins [MeSH Descriptor]
gene_encodes_gene_product
- Heterotrimeric G Protein Subunit Gene [NCIt concept]
gene_product_has_biochemical_function
- G Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
has_gene_product_element
- G Beta-Gamma [NCIt concept]
- G(i) Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-11 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-12 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(k) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein G(o) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein G(q) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short [NCIt concept]
- Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms XLas [NCIt concept]
- Guanine Nucleotide-Binding Protein G(z) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-11 [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-12 [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-13 [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Beta-5 [NCIt concept]
- Heterotrimeric G Protein Subunit [NCIt concept]

Keyword's position in hierarchy(ies) :

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