G(i) Alpha - CISMeF

Preferred Label : G(i) Alpha;

NCIt synonyms : G Protein Alpha Inhibiting Polypeptide; Adenylate Cyclase-Inhibiting G Alpha Protein; G(i) Alpha Protein; G-i Alpha;

NCIt definition : Human G(i) Alpha Proteins (G-Alpha 1 Family) are 40-kDa guanine nucleotide-binding alpha protein subunits of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase and regulate other plasma membrane enzymes are substrates for pertussis toxin. (NCI);

Details

Origin ID

C19275;

UMLS CUI

C1333649;

Automatic exact mappings (from CISMeF team)
- GTP-Binding protein alpha subunits, Gi-Go [MeSH Descriptor]
Biochemical function of gene products
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(o) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein G(z) Subunit Alpha [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_product_has_biochemical_function
- Heterotrimeric G Protein Subunit [NCIt concept]
gene_product_is_physical_part_of
- Heterotrimeric G Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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