Latent Membrane Protein 2

Preferred Label : Latent Membrane Protein 2;

NCIt synonyms : EBV LMP-2; Latent Membrane Protein-2; LMP-2; EBV Latent Membrane Protein 2; TP; Terminal Protein; LMP2; EBV LMP2;

NCIt definition : Latent membrane protein 2 (497 aa, 53 kDa) is encoded by the Epstein-Barr virus (EBV) LMP2 gene. This protein is involved in maintaining latent infection by EBV in B-lymphocytes.;

NCIt note : The Epstein-Barr virus (EBV) LMP2 gene can yield two transcripts, LMP2A and LMP2B, which result from alternative promoter usage. The two mRNA differ only in the sequences derived from the first exon. LMP2A is the canonical isoform and its role in viral latency is well established. The role of LMP2B in EBV infection is not clear. (UniProt);

NCI Metathesaurus CUI : CL503701;

Details

Origin ID

C177543;

UMLS CUI

C5444129;

Automatic exact mappings (from CISMeF team)
- EBV-associated membrane antigen, Epstein-Barr virus [MeSH Supplementary Concept]
- Prothrombin time (PT) [LOINC component]
- Thymidine phosphorylase [OMIM gene]
- Thymopoietin [OMIM gene]
- panic disorder [MeSH Descriptor]
- prothrombin time [MeSH Descriptor]
- thymopoietin [ORDO Gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Viral Gene [NCIt concept]
gene_product_has_organism_source
- Virus [NCIt concept]
is_target
- Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes [NCIt concept]
- Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes [NCIt concept]
- DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes [NCIt concept]
- LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes [NCIt concept]
- TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients