Preferred Label : LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes;
NCIt synonyms : LMP2-specific IL-12 Secreting TCR-T Cells; LMP2-specific IL-12 Secreting TCR-transduced T-lymphocytes; LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to encode a T-cell
receptor (TCR) specific for Epstein-Barr virus (EBV) latent membrane protein (LMP)
2, with potential antineoplastic activity. Upon administration, the LMP2-specific
IL-12 secreting TCR-transduced T-lymphocytes (TCR-T) recognize and bind to EBV LMP2,
which may promote cell death and inhibit the growth of tumor cells expressing LMP2.
In addition, IL-12 expression activates the immune system by promoting the secretion
of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic
T-cell responses, which may result in both decreased cell proliferation and increased
cell death in LMP2-expressing tumor cells. As a tumor associated antigen (TAA), LMP2
is expressed in various EBV-associated malignancies including nasopharyngeal cancer
and EBV-positive Hodgkin lymphoma.;
NCI Metathesaurus CUI : CL1647831;
Origin ID : C178337;
UMLS CUI : C5554962;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
