Preferred Label : Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes;
NCIt synonyms : Allogeneic LMP1 LMP2-Specific Cytotoxic T-Lymphocytes;
NCIt definition : A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to the Epstein-Barr
virus (EBV) latent membrane proteins (LMP) 1 and 2, with potential antineoplastic
activity. Peripheral blood mononuclear cells (PBMC) are collected from a donor and
are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient
adenovirus encoding EBV LMP1/2 to generate LMP1/2-specific CTL which are subsequently
expanded. Administration of allogeneic LMP1-/LMP2- specific CTL to patients with LMP1/2-positive
tumors may result in a specific CTL response against tumor cells expressing LMP1 and
LMP2, resulting in cell lysis and inhibition of tumor cell proliferation. As tumor
associated antigens (TAAs), LMP1 and LMP2 are expressed in various malignancies including
nasopharyngeal cancer and EBV-positive Hodgkin lymphoma.;
NCI Metathesaurus CUI : CL383592;
Origin ID : C78201;
UMLS CUI : C2697996;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
