Preferred Label : TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes;
NCIt synonyms : TGF-beta-Resistant LMP-Specific CTLs; TGF-b-Resistant LMP-Specific Cytotoxic T-Lymphocytes;
NCIt definition : A preparation of transforming growth factor-beta (TGF-beta)-resistant cytotoxic T-lymphocytes
(CTL) reactive to Epstein-Barr virus (EBV) latent membrane proteins 1 and 2 (LMP 1
and 2) with potential antineoplastic activity. T lymphocytes are transduced with a
retroviral vector expressing the dominant-negative mutant type II TGF-beta receptor,
which blocks signaling by all three TGF-beta isoforms. These TGF-beta-resistant T-lymphocytes
are exposed ex-vivo to dendritic cells (DCs) transfected with a replication-deficient
adenovirus encoding EBV LMP; subsequent exposure to LMP1- or LMP2-expressing lymphoblastoid
cell lines is used to expand the CTL. Administered to patients with EBV-positive tumors,
TGF-beta-resistant LMP-specific CTL target LMP-positive cells, which may result in
a specific CTL response, followed by cell lysis and inhibition of tumor cell proliferation.
Tumor-expressed TGF-beta inhibits T lymphocyte activation and expansion.;
NCI Metathesaurus CUI : CL387741;
Origin ID : C77859;
UMLS CUI : C2699753;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
